Our Sadie has been tested by
Embark
and she is clear on 182 DNA clinical traits and
Sadie is not a carrier
for any of the genetic conditions that Embark tests
for.
Sadie has also been tested and is clear for 9 genetic conditions that are common in her breed which are listed below.
Progressive Retinal Atrophy, prcd
PRA-prcd is a retinal disease that causes progressive, non-painful vision loss. The retina contains cells, called photoreceptors, that collect information about light and send signals to the brain. There are two types of photoreceptors: rods, for night vision and movement, and cones, for day vision and color. This type of PRA leads to early loss of rod cells, leading to night blindness before day blindness.
Seen in Golden Retrievers but not our Sadie.
Golden Retriever Progressive Retinal Atrophy 1, GR-PRA1
Golden Retriever PRA 1 is a retinal disease that causes progressive, non-painful vision loss. The retina contains cells, called photoreceptors, that collect information about light and send signals to the brain. There are two types of photoreceptors: rods, for night vision and movement, and cones, for day vision and color. This type of PRA leads to early loss of rod cells, leading to night blindness before day blindness.
Seen in Golden Retrievers but not our Sadie.
Golden Retriever Progressive Retinal Atrophy 2, GR-PRA2
Golden Retriever PRA 2 is a retinal disease that causes progressive, non-painful vision loss. The retina contains cells, called photoreceptors, that collect information about light and send signals to the brain. There are two types of photoreceptors: rods, for night vision and movement, and cones, for day vision and color. This type of PRA leads to early loss of rod cells, leading to night blindness before day blindness.
Seen in Golden Retrievers but not our Sadie.
Neuronal Ceroid Lipofuscinosis or NCL
A lysosome is a structure within the cell that digests and removes waste. When the lysosome cannot recycle waste properly, the waste accumulates and causes the cell to die. This form of lysosomal storage disease causes juvenile to adult onset neurologic signs.
Seen in Golden Retrievers but not our Sadie.
Degenerative Myelopathy, DM
The dog equivalent of Amyotrophic Lateral Sclerosis, or Lou Gehrig’s disease, DM is a progressive degenerative disorder of the spinal cord. Because the nerves that control the hind limbs are the first to degenerate, the most common clinical signs are back muscle wasting and gait abnormalities.
Seen in Golden Retrievers but not our Sadie.
Muscular Dystrophy
All known mutations for muscular dystrophy lie in the DMD gene, which produces the protein dystrophin. Dogs affected with MD have abnormally low levels of functional dystrophin, leading to muscle fiber damage, progressive muscle wasting, and weakness.
Seen in Golden Retrievers but not our Sadie.
Dystrophic Epidermolysis Bullosa
This condition arises from a mutation in Collagen Type VII. Collagens of all types anchor the layers of our skin together: they are what gives skin its springy, youthful texture (and thus are a big component of anti-wrinkle creams). Collagen Type VII has the specific job of connecting the epidermis, the surface layer of the skin, to the underlying tissues, leading to dogs with especially stretchy skin that is easily detached from the underlying tissues.
Seen in Golden Retrievers but not our Sadie.
Ichthyosis
This skin disorder gets its name from the thick, darkly pigmented scales of skin ("ichthys" is Greek for "fish") that affected dogs display on their noses, paw pads, and muzzles. Almost half of all Golden Retrievers has this disorder.
Seen in Golden Retrievers but not our Sadie.
Osteogenesis Imperfecta
Osteogenesis Imperfecta, Brittle Bone Disease
Our bones are equal parts rigid and flexible, making them capable of withstanding high impact as well as constant tension from attached muscle tendons and ligaments. Dogs affected with OI have lost the flexible part of the bone, which is primarily made of Type I collagen. This leads to extremely brittle bones and teeth. Type I collagen is also important in joints; as such, affected dogs can also present with hyperflexible joints and joint pain.
Seen in Golden Retrievers but not our Sadie.
They are more than just pets...They are member's of our family.